Saturday, 24 Oct 2020
Page: 57
Volume 28, Issue 10(209) 2018

Monitoring oseltamivir resistance in influenza viruses isolated from Northern Vietnam, 2013-2017

Author: Hoang Vu Mai Phuong, Le Thi Thanh, Nguyen Vu Son, Ung Thi Hong Trang, Vuong Duc Cuong, Pham Thi Hien, Tran Thu Huong, Hoang Thu Huong, Nguyen Phuong Anh, Trinh Son Tung and Nguyen Le Khanh Hang
Oseltamivir resistance in influenza viruses has been monitored since 2009 at the National Influenza Centre, National Institute of Hygiene and Epidemiology, Vietnam followed the Wold Health Organization (WHO) protocol. The strategy for assessing oseltamivir resistance was implemented including the half maximal inhibitory concentration (IC50) value determination by the neuraminidase inhibition (NAI) assay and the sequence analysis of nucleotides substitution on neuraminidase (NA) gene. Total 454 influenza virus isolates collected from influenza-like illness, severe acute respiratory infection and severe viral pneumonia patients during the 2013-2017 period. The NAI assay results showed that the IC50 value for A/H1N1pdm09 was 0.371 ± 0.28 nM, for A/H3N2 was 0.247 ± 0.2 nM, and for influenza B viruses was 10,243 ± 4,307nM. Two A/H1N1pdm09 islolates had the IC50 value at the highly reduced oseltamivir susceptibility level (1.6%), belonged to SARI patients. The mutation related to oseltamivir resistance was identified as H275Y on both NA proteins. Thus, monitoring oseltamvir resistance in severe acute respiratory infection patients is necessary in the influenza surveillance system
influenza resistance; oseltamivir; Northern Vietnam
.pdf 7. Hoang Vu Mai Phuong.pdf
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