Thursday, 19 Sep 2019
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Page: 93
Volume XXV, Issue 2(162) 2015
HIV infection in HIV-exposed children under 18 months and related factors in north and north central Vietnam in 2011–2013
Author: Nguyen Thanh Binh, Tran Hong Tram, Nguyen Viet Nga, Phan Thi Thu Huong and Nguyen Anh Tuan
Summary:
Early infant HIV diagnosis has been implemented in Vietnam since 2009. In this study, 1606 laboratory records of HIV-exposed children in 25 northern provinces and four north-central provinces in Vietnam from 2011 to 2013 were reviewed to describe HIV infection in children less than 18 months old that are born to HIV-positive mothers and its associated factors. Results showed that the prevalence of HIV-positive children was significantly reduced from 2011 (10.6%) to 2013 (6.5%). Transmission rate was the lowest among infants under 8 weeks old (3.3%) and increased with age. The highest transmission rate was found among infants 48 weeks old or older (50.9%). Transmission rates in mothers who tested positive for HIV before pregnancy, during pregnancy, at birth, and after birth were 1.4%, 4.6%, 10.2%, and 58.1%, respectively. The transmission rate in breastfeeding infants was the highest (56.9%) and was considerably lower in the non-breastfeeding group (4.4%). In addition, the transmission rate in children whose mothers were on antiretroviral therapy for treatment or prophylaxis was 4.4%, which is five-fold lower than those whose mothers did not received antiretroviral drug (ARV) (20.4%). The transmission rate among ARV prophylaxis children was 3.3%, whereas that in the non-ARV group was 31.5%. Considerably reduced mother-to-child transmission (MTCT; 3%) was observed in infants treated with all three intervention methods, including maternal ARV during pregnancy or delivery, no breastfeeding, and ARV for infants after birth, compared with infants that did not receive prophylaxis (59.3%) and those with one to two prophylaxis measures applied (10.9%). The use of preventative MTCT interventions, including ARV for mothers, ARV for infants, and no breastfeeding, contributed to the reduction of the vertical transmission rate
Keywords:
early infant HIV diagnosis, mother to child transmission, HIV, ARV drug, north and north central Vietnam
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Happy New Year 2019! Year of the Pig
The Vietnam Journal of Preventive Medicine wish all readers with healthy, happiness and prosperity in the year of the Pig. Happy New Year 2019
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